Intercomparison of S-Factor values calculated in Zubal voxelized phantom for eleven radionuclides commonly used in...

In this study we aimed at comparing various radionuclides ordinarily used in targeted prostate cancer therapy, thereby evaluating S-Factor parameter in the prostate organs as well as in its surrounding healthy tissues, namely the urinary bladder and rectum. InterDosi code version 1.1 was used to estimate S-Factor values in Zubal voxelized phantom for 11 radionuclides, namely ²²⁵Ac, ²¹At, ⁶⁷Cu, ¹²⁵I, ¹³¹I, ²¹²Pb, ¹⁷⁷Lu, ²²³Ra, ¹⁶¹ Tb, ²²⁷Th and ⁹⁰Y. The prostate organ was considered the source of different ionizing radiation emitted by the radionuclides cited above. The results showed that among all studied alpha-emitting radionuclides, ²²⁵ Ac, ²²³ Ra and ²²⁷ Th provide equidistantly the highest self-irradiation S-Factors whereas, ²¹¹At provides the lowest cross-irradiation S-Factors. On the other hand, considering only beta-emitting radionuclides, it is shown that ¹⁷⁷Lu and ⁹⁰Y induce respectively lowest and highest cross-absorption S-Factors on the surrounding healthy organs. We conclude that ¹⁷⁷Lu and ²¹¹At are more adequate for prostate radionuclide therapy because they can relatively prevent surrounding organs from radiation toxicity and at the same time provide sufficient dose to treat the prostate tumor.