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Nanomaterials for NIR-II Photoacoustic Imaging
Shanshan Jiang1, Jing Lin1, Peng Huang1
1Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, 518060, P. R. China.
Advanced Healthcare Materials
|November 3, 2022
Summary
Second near-infrared window (NIR-II) photoacoustic imaging (PAI) offers superior depth and clarity over NIR-I. This review highlights advanced nanomaterials enabling enhanced NIR-II PAI for biomedical applications.
Area of Science:
- Biomedical Optics
- Nanotechnology
- Medical Imaging
Background:
- Photoacoustic imaging (PAI) in the second near-infrared window (NIR-II, 1000-1700 nm) presents significant advantages over the first near-infrared window (NIR-I, 700-1000 nm).
- These advantages include reduced background noise, enhanced tissue penetration depth, and a higher maximum permissible exposure.
- NIR-II PAI is emerging as a key research area due to its improved performance.
Purpose of the Study:
- To review recent advancements in nanomaterials designed for NIR-II PAI.
- To summarize the benefits of NIR-II PAI and its applications in the biomedical field.
- To discuss future opportunities and challenges in NIR-II PAI.
Main Methods:
- Classification of nanomaterial-based photoacoustic contrast agents into organic, inorganic, and hybrid categories.
- Review of various organic agents: assembled small molecules, conjugated polymers, semiconducting polymers, and phthalocyanines.
- Review of various inorganic agents: metal sulfides, noble metals, carbon nanomaterials, quantum dots, MXenes, and semimetals.
- Review of organic/inorganic hybrid nanomaterials.
Main Results:
- Nanomaterials are effectively utilized as contrast agents in NIR-II PAI.
- Applications include imaging and diagnosis of tumors, brain vasculature, and inflammation.
- These agents also facilitate in vivo monitoring of catalytic reaction processes.
Conclusions:
- Nanomaterials are crucial for advancing NIR-II PAI technology.
- NIR-II PAI holds great promise for various biomedical diagnostic and monitoring applications.
- Further research is needed to address existing challenges and unlock the full potential of NIR-II PAI.
