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Synthesis of α-Aminoacetals via Decarboxylative Coupling of Imine and 2,2,-Diethoxyacetic Acid
Seoksun Kim1, Beomsoon Park2, Geun Seok Lee2
1Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Abstract:
Atom-economical C-C coupling between imines and a C1 source could provide α-aminoaldehyde derivatives. Nevertheless, such a coupling has rarely been achieved owing to the lack of appropriate nucleophilic C1 sources. In this study, photocatalytic synthesis of α-aminoacetals was achieved via decarboxylative coupling of imine and 2,2-diethoxyacetic acid using a nonstoichiometric amount of a radical initiator. Various functional groups were compatible, providing efficient one-step access to diversely functionalized α-aminoacetals, which provides a promising platform for further research.
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