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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Stimuli-responsive transdermal microneedle patches
Pooyan Makvandi1, Rezvan Jamaledin2,3, Guojun Chen4,5
1Istituto Italiano di Tecnologia, Centre for Materials interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy.
Materials Today (Kidlington, England)
|November 7, 2022
Summary
Stimuli-responsive microneedle (MN) patches offer on-demand drug release for minimally invasive delivery. This review explores their mechanisms, applications, and challenges for clinical translation.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Microneedle (MN) patches utilize miniature needles for minimally invasive transdermal delivery of biomolecules.
- Stimuli-responsive MN patches are advanced systems designed for on-demand drug release triggered by internal or external stimuli.
Purpose of the Study:
- To review various stimuli-responsive MN patches for controlled drug release.
- To discuss their mechanisms of action for different medical indications.
- To explore future opportunities and challenges for clinical translation.
Main Methods:
- Literature review of stimuli-responsive microneedle patch technologies.
- Analysis of drug release mechanisms triggered by various stimuli.
- Discussion of potential therapeutic applications and clinical hurdles.
Main Results:
- A variety of stimuli-responsive MN patch designs and their triggering mechanisms were identified.
- These patches demonstrate potential for controlled and targeted drug delivery across diverse indications.
- Key challenges for clinical translation include manufacturing scalability, stability, and regulatory approval.
Conclusions:
- Stimuli-responsive MN patches represent a significant advancement in controlled transdermal drug delivery.
- Further research and development are crucial to overcome challenges and facilitate clinical adoption.
- These systems hold promise for improving patient compliance and therapeutic outcomes.
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