Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sensory Functions of the Skin01:16

Sensory Functions of the Skin

5.4K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
5.4K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

438
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
438

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Smart metal-organic framework/polymer composites: Different stimuli and applications.

Advances in colloid and interface science·2026
Same author

Am80-lipid nanoparticles serve as an enteric mucosal adjuvant following parenteral immunization with inactivated polio vaccine.

Science advances·2026
Same author

Interfacial viscoelastic response in electrically deformed picoliter droplets of synthetic urine.

Journal of colloid and interface science·2026
Same author

Microneedle array platforms for drug delivery and biomarker sensing: From skin mechanics guided design to scalable manufacture for clinical utility.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Multiplex Detection and Quantification of miRNAs in Drug Delivery Systems Using a Signal-Off Electrochemical Platform.

Analytical chemistry·2026
Same author

Surface-confined FRET nanoplatform printed <i>via</i> pyro-EHD jet for stable and reproducible TNF-α detection.

RSC advances·2026

Related Experiment Video

Updated: Aug 22, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.5K

Stimuli-responsive transdermal microneedle patches.

Pooyan Makvandi1, Rezvan Jamaledin2,3, Guojun Chen4,5

  • 1Istituto Italiano di Tecnologia, Centre for Materials interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy.

Materials Today (Kidlington, England)
|November 7, 2022
PubMed
Summary

Stimuli-responsive microneedle (MN) patches offer on-demand drug release for minimally invasive delivery. This review explores their mechanisms, applications, and challenges for clinical translation.

More Related Videos

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.4K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.3K

Related Experiment Videos

Last Updated: Aug 22, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.5K
Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.4K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.3K

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Microneedle (MN) patches utilize miniature needles for minimally invasive transdermal delivery of biomolecules.
  • Stimuli-responsive MN patches are advanced systems designed for on-demand drug release triggered by internal or external stimuli.

Purpose of the Study:

  • To review various stimuli-responsive MN patches for controlled drug release.
  • To discuss their mechanisms of action for different medical indications.
  • To explore future opportunities and challenges for clinical translation.

Main Methods:

  • Literature review of stimuli-responsive microneedle patch technologies.
  • Analysis of drug release mechanisms triggered by various stimuli.
  • Discussion of potential therapeutic applications and clinical hurdles.

Main Results:

  • A variety of stimuli-responsive MN patch designs and their triggering mechanisms were identified.
  • These patches demonstrate potential for controlled and targeted drug delivery across diverse indications.
  • Key challenges for clinical translation include manufacturing scalability, stability, and regulatory approval.

Conclusions:

  • Stimuli-responsive MN patches represent a significant advancement in controlled transdermal drug delivery.
  • Further research and development are crucial to overcome challenges and facilitate clinical adoption.
  • These systems hold promise for improving patient compliance and therapeutic outcomes.