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Updated: Aug 22, 2025

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Methotrexate pneumonitis in a patient with gestational trophoblastic neoplasia
M Agarwal1, K K Sharma1, K Deokar2
1Department of Pulmonary Medicine, Eternal Hospital Care Center, Jaipur, Rajasthan, India.
Abstract:
Methotrexate, an immunomodulatory agent used for a wide variety of indications, can cause pulmonary toxicity in the form of pneumonitis, organising pneumonia, pulmonary fibrosis, pleural effusion, pulmonary infections or lymphoproliferative disease. We report a case of methotrexate pneumonitis in a patient with gestational trophoblastic neoplasia. The diagnosis of methotrexate pneumonitis is challenging, as the signs and symptoms can be caused by intercurrent infection, concomitant medications or an underlying disease condition. A high index of suspicion is required for diagnosis. Management consists of drug discontinuation and steroids in patients with respiratory failure.
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