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Metronidazole-resistant trichomoniasis: Two Canadian cases
Monica Cenkowski1, Beverly Wudel2, Ingrid Baragar3
1Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Summary
Metronidazole-resistant trichomoniasis poses a significant health challenge. Tinidazole shows promise as an effective alternative treatment when metronidazole fails, especially with international susceptibility testing.
Area of Science:
- Infectious Diseases
- Clinical Microbiology
- Public Health
Background:
- Metronidazole-resistant trichomoniasis presents a growing clinical challenge, particularly in Canada where susceptibility testing is limited.
- Trichomoniasis, caused by *Trichomonas vaginalis*, is a common sexually transmitted infection.
- Limited access to diagnostics and effective treatments complicates patient management.
Observation:
- Two cases of persistent trichomoniasis are presented, both demonstrating resistance to metronidazole.
- Patients underwent multiple courses of metronidazole therapy with escalating doses without resolution.
- International culture and susceptibility testing were crucial for identifying resistance patterns.
Findings:
- Both cases revealed metronidazole resistance in *T. vaginalis* isolates.
- Tinidazole emerged as an effective second-line therapy in these cases.
- Resistance to metronidazole necessitates alternative treatment strategies.
Implications:
- Canadian clinicians need awareness of international susceptibility testing for *T. vaginalis* to manage metronidazole-resistant cases.
- Timely identification of resistance and informed treatment decisions are critical for patient outcomes.
- Developing accessible susceptibility testing in Canada is essential for addressing this health burden.
Keywords:
Trichomonas vaginalismetronidazolemétronidazoleresistantrésistanttrichomonasetrichomoniasisMore Related Videos
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