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Published on: June 9, 2023
Phytocompounds From Edible Oil Seeds Target Hub Genes To Control Breast Cancer
Soniya Ashok Kumar1, Noorul Samsoon Maharifa Haja Mohaideen1, Hemalatha S2
1School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science & Technology, Tamil Nadu, Vandalur, Chennai, 600048, India.
Sesame and sunflower seeds contain anti-cancer compounds that may help fight breast cancer. This study identifies potential phytocompounds in these seeds for targeted drug and food product development.
Area of Science:
- Oncology
- Nutritional Science
- Computational Biology
Background:
- Breast cancer is a leading global cancer in women, with CCNA2, CCNB1, MAD2L1, and RAD51 identified as key hub genes.
- Diet and lifestyle significantly influence cancer development, highlighting the importance of cancer-fighting foods like seeds.
Purpose of the Study:
- To identify potential anti-cancer phytocompounds in sesame and sunflower seeds.
- To investigate the interaction of these phytocompounds with breast cancer hub genes (CCNA2, CCNB1, MAD2L1, RAD51).
- To provide a basis for developing targeted pharmaceutical drugs and functional food products.
Main Methods:
- Utilized molecular docking and dynamic simulation techniques.
- Analyzed phytocompounds present in sesame (Sesamum indicum) and sunflower (Helianthus annuus L.) seeds.
- Focused on interactions with identified breast cancer-associated genes.
Main Results:
- Identified specific phytocompounds within sesame and sunflower seeds with potential anti-cancer properties.
- Demonstrated the potential of these phytocompounds to interact with breast cancer hub genes.
- Provided insights into the molecular mechanisms of seed-derived compounds against breast cancer.
Conclusions:
- Sesame and sunflower seeds possess bioactive compounds with potential therapeutic applications against breast cancer.
- The identified phytocompounds and their interactions with hub genes offer promising avenues for novel drug discovery and functional food development.
- This research supports the integration of dietary strategies and targeted therapies for breast cancer prevention and treatment.
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