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Updated: Aug 22, 2025

09:54
Laboratory Scale Production and Purification of a Therapeutic Antibody
Published on: January 24, 2017
17.5K
Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics
Florian Heinkel1, Meghan M Verstraete1, Siran Cao1
1Zymeworks Inc., Vancouver, BC, Canada.
Mabs
|November 7, 2022
Abstract
Abbreviations:
CE-SDS: capillary electrophoresis sodium dodecyl sulfate; DSC: differential scanning calorimetry; FACS: fluorescence-activated cell sorting; FSA: full-sized antibody; Her2: human epidermal growth factor receptor 2; MFI: mean fluorescent intensity; OAA: one-armed antibody; PBS: phosphate-buffered saline; PDB: Protein Data Bank; SEC: size-exclusion chromatography; prepSEC (preparative SEC); RMSD: root-mean-square deviation; RU: resonance units; SPR: surface plasmon resonance; TAA: tumor-associated antigen; WT: wild-type.

