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Bioinorganic supramolecular coordination complexes and their biomedical applications
Guillermo Moreno-Alcántar1, Angela Casini1
1Department of Chemistry, Technical University of Munich (TUM), Garching bei München, Germany.
FEBS Letters
|November 8, 2022
Summary
Bioinorganic supramolecular chemistry utilizes metal-based supramolecules formed via coordination-driven self-assembly (CDSA). These versatile materials show promise in biomedicine for applications like biosensing, imaging, and drug delivery.
Area of Science:
- Bioinorganic Supramolecular Chemistry
- Coordination Chemistry
- Materials Science
Background:
- Emerging field focusing on metal-based supramolecules.
- Coordination-driven self-assembly (CDSA) links metal ions and organic ligands.
- Supramolecular coordination complexes are discrete entities formed by CDSA.
Purpose of the Study:
- Review the state-of-the-art of supramolecular coordination complexes in biomedicine.
- Highlight versatile, multifunctional materials derived from CDSA.
- Discuss challenges and future directions in the field.
Main Methods:
- Focus on supramolecular coordination complexes formed by CDSA.
- Summarize current applications in molecular recognition, biosensing, therapy, imaging, and drug delivery.
- Present selected representative examples of these systems in biomedicine.
Main Results:
- Supramolecular coordination complexes are a new class of versatile multifunctional materials.
- These materials have broad biological applications.
- CDSA provides an accessible route to these complex structures.
Conclusions:
- Bioinorganic supramolecular chemistry offers promising avenues for biomedical applications.
- Further research is needed to address challenges and explore new directions.
- CDSA-based supramolecular coordination complexes represent a significant advancement in materials science for healthcare.
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