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Updated: Aug 22, 2025

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

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From neonatal lung function to lung function and respiratory morbidity at 6-year follow-up

Fanny E M Goth1,2, Kent Green1, Bo M Hansen1,2

  • 1Department of Pediatrics and Adolescence Medicine, Nordsjaellands Hospital, Hillerod, Denmark.

Pediatric Pulmonology
|November 9, 2022
PubMed

Insights

Moderate to late preterm children show reduced lung function by age 6 compared to term-born peers. Neonatal breathing patterns did not predict later respiratory issues in this small study.

Area of Science:

  • Pediatric Pulmonology
  • Neonatal Medicine
  • Respiratory Physiology

Background:

  • Longitudinal lung function tracking from infancy to adulthood is crucial.
  • Limited data exists on lung function development in moderate to late preterm infants.
  • Understanding prematurity's impact on childhood respiratory health is vital.

Purpose of the Study:

  • To assess lung function at age 6 in moderate to late preterm children.
  • To compare respiratory outcomes with term-born children.
  • To investigate the relationship between neonatal lung function and later respiratory health.

Main Methods:

  • Compared lung function of moderate to late preterm (n=48) and term-born (n=53) infants.
  • Neonatal measurements included Fractional Exhaled Nitric Oxide (FeNO) and tidal breathing flow-volume loops (TBFVL).
  • Age 6 assessments utilized spirometry, whole-body plethysmography, and respiratory symptom questionnaires.

Main Results:

  • Preterm infants had higher neonatal TPEF/TE ratios (42.6% vs. 33.7%).
  • Children born moderate to late preterm exhibited lower % predicted forced expiratory volume in 1 second at age 6 (94.4% vs. 101.9%).
  • Neonatal tidal volume variability correlated with airway resistance at age 6 (β=-0.34).

Conclusions:

  • Moderate to late preterm birth is associated with diminished lung function at age 6.
  • Neonatal tidal breathing parameters were not predictive of subsequent respiratory morbidity or lung function.
  • Further research with larger cohorts is needed to confirm these findings.
Abstract

Keywords:
asthma and early wheezeneonatal pulmonary medicinepulmonary function testing

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