In Vivo Measurements of Transcranial Electrical Stimulation in Lesioned Human Brain: A Case Report

Transcranial electrical stimulation (tES) has been utilized widely in populations with brain lesions, such as stroke patients. The tES-generated electric field (EF) within the brain is considered as one of the most important factors for physiological effects. However, it is still unclear how brain lesions may influence EF distribution induced by tES. In this case study, we reported in vivo measurements of EF in one epilepsy participant with brain lesions during different tES montages. With the in vivo EF data measured by implanted stereo-electroencephalography (sEEG) electrodes, the simulation model was investigated and validated. Our results demonstrate that the prediction ability of the current simulation model may be degraded in the lesioned human brain.