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Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
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Defense Mechanism Against Infection01:26

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Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
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Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

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The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
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Introduction to the Integumentary System01:25

Introduction to the Integumentary System

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The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
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Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

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The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Updated: Aug 22, 2025

Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran
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Skin Barrier Function and the Microbiome.

Hyun-Ji Lee1, Miri Kim1

  • 1Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #10, 63-ro, Yeongdeungpo-gu, Seoul 07345, Korea.

International Journal of Molecular Sciences
|November 11, 2022
PubMed
Summary
This summary is machine-generated.

The skin microbiome and its barrier function are intricately linked. Dysbiosis, or imbalance, in the skin microbiome contributes to inflammatory skin diseases, but microbiome cosmetics offer potential therapeutic benefits.

Keywords:
acneatopic dermatitismicrobiomepsoriasisskin barrier

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Area of Science:

  • Dermatology and Microbiology
  • Human Microbiome Research

Background:

  • The human skin microbiome comprises microorganisms interacting with the skin barrier.
  • These interactions influence skin health through physical, chemical, and immunological mechanisms.

Purpose of the Study:

  • To review recent insights into the skin microbiome's symbiotic relationship with the skin barrier.
  • To explore the gut-skin axis and microbiome dysbiosis in inflammatory skin conditions.
  • To examine the therapeutic potential of microbiome cosmetics.

Main Methods:

  • Literature review of symbiotic relationships between skin microbiome and barrier function.
  • Discussion of the gut-skin axis and its influence.
  • Analysis of microbiome dysbiosis in inflammatory skin diseases.

Main Results:

  • The skin microbiome significantly impacts skin barrier function via multiple pathways.
  • Microbiome dysbiosis is implicated in inflammatory skin diseases like acne, atopic dermatitis, and psoriasis.
  • The gut-skin axis plays a role in maintaining skin barrier integrity.

Conclusions:

  • Restoring skin barrier function and improving inflammatory skin diseases may be achieved through microbiome modulation.
  • Microbiome cosmetics show promise in managing skin barrier dysfunction and associated conditions.