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Gut Microbiome and Its Cofactors Are Linked to Lipoprotein Distribution Profiles
Josué L Castro-Mejía1, Bekzod Khakimov1, Violetta Aru1
1Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark.
Microorganisms
|November 11, 2022
Summary
The gut microbiome influences lipid levels. Specific bacteria like Ruminococcaceae and Christensenellaceae are linked to healthier lipoproteins, while others associate with dyslipidemia, highlighting the gut microbiome
Area of Science:
- Microbiology
- Metabolic Health
- Human Physiology
Background:
- Growing evidence links gut microbiome (GM) to dyslipidemia.
- Limited in-depth characterization of GM and lipoprotein distributions (LPD) across diverse BMIs exists.
Purpose of the Study:
- To characterize associations between GM composition and LPD in adults.
- To explore the role of SCFA and B-vitamin metabolism in these associations.
Main Methods:
- Studied 262 Danish adults (aged 19-89 years).
- Analyzed blood-plasma LPD, fecal short-chain fatty acids (SCFA), and GM composition.
- Utilized metagenome sequencing and metagenomic-assembled genomes (MAGs).
Main Results:
- LPD profiles stratified into three clusters, influenced by age and BMI.
- Specific bacteria (Ruminococcaceae, Christensenellaceae) linked to higher HDL subfractions.
- Other bacteria (Lachnospiraceae, Coriobacteriaceae) associated with increased total cholesterol and LDL.
- Healthier LPD profiles showed higher abundance of B-vitamin and SCFA metabolism genes.
Conclusions:
- Gut microbiome composition and metabolic functions are associated with lipoprotein distribution variations.
- Findings support the gut microbiome's role in the gut-dyslipidemia axis.
- Highlights potential for microbiome-targeted interventions for dyslipidemia.
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