Surface Functionalization of Nanofibers: The Multifaceted Approach for Advanced Biomedical Applications

Area of Science:

• Biomedical Engineering
• Materials Science
• Nanotechnology

Background:

• Nanofiber technology is crucial for drug delivery, tissue engineering, and diagnostics.
• Surface functionalization modifies nanofiber properties for enhanced applications.
• Diverse materials are used for surface modification, including polymers and metals.

Purpose of the Study:

• To provide a comprehensive review of nanofiber surface functionalization techniques.
• To explore the biomedical applications of functionalized nanofibers.
• To assess toxicity and analyze the global patent landscape.

Main Methods:

• Electrospinning of nanofibers.
• Surface modification techniques for nanofibers.
• Analysis of physicochemical and biological property changes.

Main Results:

• Surface functionalization significantly alters nanofiber wettability, thermal properties, cell adhesion, and biocompatibility.
• Functionalized nanofibers show promise in tissue engineering, wound healing, cancer treatment, and disease diagnosis.
• Drug delivery via functionalized nanofibers improves drug permeation and bioavailability.

Conclusions:

• Surface functionalization is key to unlocking the full potential of nanofibers in biomedicine.
• Functionalized nanofibers offer improved therapeutic efficacy and targeted disease treatment.
• Further research into toxicity and patenting is essential for clinical translation.