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Author Spotlight: Optimizing Apoplast Protein Extraction for Efficient Recovery of Recombinant Proteins from Plant Cells
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Recent Progress on Vaccines Produced in Transgenic Plants.

Goabaone Gaobotse1, Srividhya Venkataraman2, Kamogelo M Mmereke1

  • 1Department of Biological Sciences & Biotechnology, Botswana International University of Science & Technology, Palapye, Botswana.

Vaccines
|November 11, 2022
PubMed
Summary
This summary is machine-generated.

Plant-made vaccines offer a promising avenue for rapid vaccine development, especially during pandemics like COVID-19. Continued research aims to overcome production challenges and optimize protocols for safe and effective plant-derived vaccines.

Keywords:
downstream processingexpressionimmunogenicityplant molecular pharmingplant-made vaccinerecombinant proteintransgenic plantvaccine

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Area of Science:

  • Biotechnology and Molecular Biology
  • Vaccinology
  • Plant Science

Background:

  • Plant-made vaccine development has progressed for over 20 years, facing persistent challenges in commercialization.
  • The COVID-19 pandemic highlighted the critical need for rapid and scalable vaccine production.
  • Transgenic plants offer a potential platform for producing vaccines against various human diseases.

Purpose of the Study:

  • To review recent advancements (past 5 years) in plant-made vaccine development for human diseases.
  • To analyze different plant host species and expression systems for recombinant protein production.
  • To discuss strategies for optimizing vaccine production protocols, focusing on protein recovery and purification.

Main Methods:

  • Comprehensive literature review of studies on plant-made vaccines over the last five years.
  • Analysis of host plant species and expression system characteristics, including advantages and disadvantages.
  • Examination of current protocols for recombinant protein production, purification, and optimization in plants.

Main Results:

  • Several plant-made human vaccines are currently in clinical trials, demonstrating progress.
  • Various plant expression systems exhibit distinct benefits and limitations for recombinant protein production.
  • Optimization of production protocols is crucial for improving the efficiency and yield of plant-derived vaccines.

Conclusions:

  • Plant-made vaccines hold significant potential for addressing global health challenges, including pandemics.
  • Overcoming technical and regulatory hurdles is essential for the successful commercialization of plant-derived vaccines.
  • Further research into host systems and production optimization will enhance the viability of this technology.