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Updated: Aug 22, 2025

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
Early detection and prevention of head and neck cancers
1Senior Specialty Registrar in Oral and Maxillofacial Surgery, Gloucestershire Hospitals NHS Foundation Trust, Gloucestershire, UK. p.glen@doctors.org.uk.
Abstract:
Squamous cell carcinoma forms the vast majority of head and neck malignancies, with advanced disease incurring poor long-term survival. Early detection and prompt specialist referral allows the patient a greater chance of cure. Furthermore, basal cell carcinoma is the most common malignancy in humans, with the vast majority presenting in the head and neck region. Dentists have a unique opportunity to assess for cutaneous malignancies during routine visits.Cancer screening should be common practice within dental professionals. In addition to enquiring about common red flag symptoms, a comprehensive and systematic extra- and intra-oral examination should be undertaken at each new and check-up appointment. Urgent referral to an appropriate secondary care provider should be made at the earliest opportunity where concern for cancer exists.
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