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To kill or not to kill - The role of the tumor microenvironment in shaping group 1 ILC functions
Nils Christian Müller1, Chiara Romagnani2
1Innate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association, Virchhowweg 12, 10117 Berlin, Germany.
Abstract:
Group 1 innate lymphoid cells (ILC) comprise two major IFN-γ producing populations, namely Natural Killer (NK) cells, and ILC1s. Recent studies have revealed a complex and diverse composition of group 1 ILC subsets infiltrating different tumors. In this review, we will outline the commonalities and differences between group 1 ILC subsets in both mice and humans, discuss how the tissue and tumor microenvironment shapes their phenotype and functions, as well as describe their contrasting roles in the response to different cancers.
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