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Updated: Aug 22, 2025

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Intermolecular amide and aldehyde interactions: rotational spectroscopy of the complexes of formaldehyde with
Liuting Wang1, Tingting Yang1, Zhen Wang1
1School of Chemistry and Chemical Engineering, Chongqing University, Daxuecheng South Road. 55, 401331, Chongqing, China. fengg@cqu.edu.cn.
Abstract:
The binary intermolecular complexes of amides and formaldehyde can be taken as suitable models to investigate the non-covalent interactions of a peptide with the carbonyl group. We herein studied the rotational spectra of the model complexes of 2-azetidinone-H2CO and formamide-H2CO generated in a helium supersonic jet. For each complex, one rotational spectra featuring hyperfine structures caused by the 14N quadrupole coupling effect was observed and assigned to its global minimum conformation. The detected isomers of both studied complexes are stabilized by a dominant amide hydrogen bond N-H⋯OC and a weaker C-H⋯O interaction, preferring the Cs symmetry. NBO and SAPT analyses provide quantitative estimation of the non-covalent interactions stabilizing the complexes.
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