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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

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Glomerella cingulata endophthalmitis

Nathan Gunasekaran1, Kenneth R Lee1, Andrew W Kam1,2,3

  • 1Department of Ophthalmology, Westmead Hospital, Westmead, New South Wales, Australia.

American Journal of Ophthalmology Case Reports
|November 17, 2022
PubMed
Abstract

Insights

A rare fungal infection, Glomerella cingulata, caused severe endophthalmitis in a patient. Despite aggressive treatment, the outcome was poor, highlighting the aggressive nature of this fungal species.

Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Exogenous endophthalmitis is a severe intraocular infection often leading to vision loss.
  • Fungal keratitis can progress to endophthalmitis, posing a significant clinical challenge.

Observation:

  • A case of exogenous endophthalmitis caused by Glomerella cingulata, a variant of Colletotrichum gloeosporioides, is presented.
  • The patient, a 71-year-old male, developed infectious keratitis that advanced to endophthalmitis.

Findings:

  • Vitreous culture confirmed Glomerella cingulata as the causative agent.
  • Despite prompt and comprehensive treatment with voriconazole and amphotericin B (topical, systemic, and intravitreal), the patient experienced poor visual and anatomical outcomes.

Implications:

  • Glomerella cingulata is identified as a rare but potentially devastating cause of endophthalmitis.
  • This case underscores the importance of early diagnosis and aggressive management of fungal endophthalmitis, even with novel antifungal agents.
Keywords:
Colletotrichum gloeosporioidesEndophthalmitisGlomerella cingulataKeratitis

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