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Related Experiment Video

Updated: Aug 20, 2025

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Glomerella cingulata endophthalmitis.

Nathan Gunasekaran¹, Kenneth R Lee¹, Andrew W Kam^1,2,3

¹Department of Ophthalmology, Westmead Hospital, Westmead, New South Wales, Australia.

American Journal of Ophthalmology Case Reports

|November 17, 2022

Summary

A rare fungal infection, Glomerella cingulata, caused severe endophthalmitis in a patient. Despite aggressive treatment, the outcome was poor, highlighting the aggressive nature of this fungal species.

Keywords:

Colletotrichum gloeosporioides Endophthalmitis Glomerella cingulata Keratitis

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Published on: May 31, 2024

Area of Science:

Ophthalmology
Mycology
Infectious Diseases

Background:

Exogenous endophthalmitis is a severe intraocular infection often leading to vision loss.
Fungal keratitis can progress to endophthalmitis, posing a significant clinical challenge.

Observation:

A case of exogenous endophthalmitis caused by Glomerella cingulata, a variant of Colletotrichum gloeosporioides, is presented.
The patient, a 71-year-old male, developed infectious keratitis that advanced to endophthalmitis.

Findings:

Vitreous culture confirmed Glomerella cingulata as the causative agent.
Despite prompt and comprehensive treatment with voriconazole and amphotericin B (topical, systemic, and intravitreal), the patient experienced poor visual and anatomical outcomes.

Implications:

Glomerella cingulata is identified as a rare but potentially devastating cause of endophthalmitis.
This case underscores the importance of early diagnosis and aggressive management of fungal endophthalmitis, even with novel antifungal agents.