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Related Concept Videos

Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone Formation by Endochondral Ossification01:24

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
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Juvenile aggressive ossifying fibroma.

H Jagadish Chandra1, Vinay Krishna1, Mohammed Tahir1

  • 1Department of Oral and Maxillofacial Surgery, Yenepoya Dental College, Yenepoya University, Mangalore, Karnataka, India.

National Journal of Maxillofacial Surgery
|November 17, 2022
PubMed
Summary
This summary is machine-generated.

This case report details an 11-year-old boy diagnosed with ossifying fibroma, a benign jaw tumor. Surgical resection was successful, with the patient showing satisfactory healing and no adverse effects during follow-up.

Keywords:
Biopsyfibromamandiblenonodontogenictrabeculae

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Pathology
  • Oncology

Background:

  • Ossifying fibroma is a benign, well-demarcated fibro-osseous lesion of the jaw.
  • It typically presents as a solitary lesion, most commonly in the mandible.
  • Histologically, it features a fibrous stroma with bone and cementum-like components.

Observation:

  • An 11-year-old boy presented with a 2-month history of asymptomatic swelling on the left mandibular angle.
  • Radiographic examination suggested an ossifying fibroma.
  • An incisional biopsy confirmed the diagnosis of ossifying fibroma.

Findings:

  • Surgical resection of the ossifying fibroma was performed under general anesthesia.
  • The tumor was excised, and the surgical site was closed with two-layer suturing.
  • Post-operative management included antibiotic and analgesic coverage.

Implications:

  • This case highlights the successful surgical management of ossifying fibroma in a pediatric patient.
  • Early diagnosis and surgical intervention are crucial for favorable outcomes.
  • The patient's regular follow-ups indicate a good prognosis with satisfactory healing.