Asymmetric construction of densely functionalized three-dimensional aza-tetracyclic scaffolds for drug discovery
Kohei Umedera1, Taiki Morita1,2, Hiroyuki Nakamura1,2
1School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho Midori-ku, Yokohama, 226-8503, Japan. hiro@res.titech.ac.jp.
Chemical Communications (Cambridge, England)
|November 18, 2022
Abstract:
Asymmetric construction of densely functionalized three-dimensional aza-tetracyclic scaffolds were achieved by intramolecular Diels-Alder reaction of bicyclic precursors derived from L-tyrosine. Three substituents were systematically introduced into the developed scaffolds in various combinations, demonstrating their high utility in drug discovery.
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