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Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
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Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

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Chronic Hepatitis B Virus and Hepatitis D Virus: New Developments

Ann Robinson1, Robert Wong2, Robert G Gish3

  • 1California Pacific Medical Center, 1101 Van Ness Avenue, San Francisco, CA 94109, USA.

Clinics in Liver Disease
|November 18, 2022
PubMed

Insights

Hepatitis B virus (HBV) infection causes significant global deaths, primarily from cirrhosis and liver cancer. Increased vaccination and screening efforts are crucial for eradicating this preventable disease.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Hepatitis B virus (HBV) and hepatitis D virus are major global health burdens, causing significant morbidity and mortality.
  • Despite highly effective HBV vaccines (98%-100%), an estimated 820,000 deaths occurred in 2019, primarily due to cirrhosis and hepatocellular carcinoma.
  • Disease prevalence is disproportionately high outside the United States, leading to underestimation of its impact.

Purpose of the Study:

  • To highlight the ongoing global impact of Hepatitis B virus.
  • To emphasize the need for enhanced public health strategies for HBV prevention and control.
  • To advocate for expanded vaccination and screening measures to achieve disease eradication.

Main Methods:

  • Review of global mortality data attributed to HBV.
  • Analysis of vaccination efficacy and current public health recommendations.
  • Assessment of disease sequelae, including cirrhosis and hepatocellular carcinoma.

Main Results:

  • HBV remains a leading cause of preventable deaths worldwide.
  • Cirrhosis and hepatocellular carcinoma are the primary sequelae driving mortality.
  • Current vaccination strategies, while effective, have not eradicated the disease due to concentrated prevalence outside the US.

Conclusions:

  • Expanded vaccination recommendations by the CDC are essential.
  • Routine screening and heightened healthcare provider awareness are critical.
  • A concerted public health approach is necessary to work towards the eradication of Hepatitis B virus.

Keywords:
AntiviralsHepatitis BHepatitis DHepatitis deltaVaccination

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