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Updated: Aug 20, 2025

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
Published on: June 11, 2017
Orthobiologic Treatment of Ligament Injuries
Luga Podesta1, Eric S Honbo2, Raymond Mattfeld3
1Regenerative Sports Medicine, Bluetail Medical Group Naples, FL, USA; Podesta Orthopedic & Sports Medicine Institute, Florida Everblades, 1875 Veterans Park Drive, Suite 2201, Naples, FL 34109, USA.
Abstract:
Ligament injuries are common causes of joint pain, dysfunction, and disability resulting in disruption of joint homeostasis. Ligament injuries have historically been treated surgically. The autologous orthobiologic preparation used for treatment can influence the varying results reported. Therefore, to truly understand and compare results of these powerful therapies, reporting standardization, such as harvesting techniques, concentration techniques, quantification of the delivered product (platelets, progenitor cells), formulations (leukocyte content), number of injections performed, activation, injection technique (guided vs unguided), in addition to the post treatment rehabilitation process, are all important and necessary to evaluate and compare efficacy of future studies.
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