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Orthobiologic Interventions for Muscle Injuries
Philip M Stephens1, Ryan P Nussbaum2, Kentaro Onishi3
1Physical Medicine & Rehabilitation, University of Pittsburgh Medical Center, Kaufmann Medical Building Suite 9103471 Fifth Avenue, Pittsburgh, PA 15213, USA. Electronic address: https://twitter.com/PhilipStephens1.
Abstract:
Muscle injuries represent a common problem in active populations. Orthobiologics continue to be studied for their ability to improve muscle healing. To date, the basic science research for treating muscle injuries with platelet-rich plasma or stem cell remains novel. Furthermore, there are even fewer clinical studies on these topics, and their findings are inconclusive. Reviewing the literature, muscle injuries treated with ultrasound-guided leukocyte-rich PRP injections appear to have the strongest evidence. Scar formation remains a major barrier in muscle injury healing, and there is optimism for future orthobiologic treatments that target the downregulation of TGF-B, resulting in decreased scar development.
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