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Updated: Aug 20, 2025

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo
Published on: June 29, 2022
Cutaneous Oncology in the Immunosuppressed
Leo L Wang1, Stephanie K Lin2, Carolyn M Stull1
1Department of Dermatology, Perelman Center for Advanced Medicine, University of Pennsylvania, 1st Floor South Pavilion, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Abstract:
Patients with immunosuppressive conditions experience an increased frequency and severity of cutaneous malignancies. This article highlights management of keratinocyte carcinoma, melanoma, Merkel cell carcinoma, and Kaposi sarcoma in the setting of lymphoproliferative disorders, acquired immunodeficiencies, and organ transplantation. Advances in the safety of organ transplant recipient immunosuppression, early identification of risk factors, and new targeted therapies are improving skin cancer outcomes in immunocompromised populations.
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