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Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

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Circular RNAs as a promising biomarker for heart disease

Young-Kook Kim1

  • 1Department of Biochemistry, Chonnam National University Medical School, Hwasun, Jeollanam-do, Republic of Korea.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 22, 2022
PubMed

Insights

Circular RNAs (circRNAs) show promise as biomarkers for early heart disease detection. This review summarizes circRNA research, biogenesis, and their role in diagnosing cardiac conditions using blood-based biomarkers.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Heart disease is a leading cause of mortality, necessitating novel early detection methods.
  • Circular RNAs (circRNAs) are increasingly recognized for their roles in various human diseases, including cardiac pathologies.
  • Existing literature lacks a comprehensive summary of circRNAs as heart disease biomarkers and future research directions.

Approach:

  • This review details the history and significant studies in circRNA research.
  • It explains the biogenesis of circRNAs and their potential as diagnostic markers for heart conditions.
  • The review summarizes studies utilizing circulating circRNAs in blood for heart disease detection.

Key Points:

  • CircRNAs are implicated in the pathogenesis of various heart diseases.
  • circRNAs found in blood can serve as non-invasive biomarkers for early cardiac condition diagnosis.
  • Understanding circRNA biogenesis is crucial for developing effective diagnostic tools.

Conclusions:

  • Circular RNAs represent a promising class of biomarkers for the early detection and prevention of heart disease.
  • Further research into circRNAs can significantly advance cardiovascular diagnostics and patient outcomes.
  • This review provides a foundation for researchers focusing on circRNA-based heart disease detection.

Keywords:
BiomarkerBloodCircular RNAHeart diseasePlasmaSerum

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