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Changes of Choroidal Thickness in Children after Short-Term Application of 1% Atropine Gel
Yue Zhou1, Yan Zhu1, Xiao Bo Huang1
1Department of Ophthalmology, Second Affiliated Hospital of Nantong University, Nantong, China.
Insights
One week of 1% atropine eye drops significantly increased choroidal thickness (ChT) in myopic and emmetropic children. Hyperopic children showed no significant ChT changes, except on the nasal side.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Retinal Research
Background:
- Choroidal thickness (ChT) is a key indicator of ocular health.
- Myopia and refractive errors in children are significant public health concerns.
- Understanding the effects of pharmacological agents on the choroid is crucial for pediatric eye care.
Purpose of the Study:
- To evaluate the impact of 1% atropine on choroidal thickness (ChT) in children with myopia, emmetropia, and hyperopia.
- To determine if atropine's effect on ChT differs based on refractive status in pediatric populations.
Main Methods:
- A cohort of 235 children (aged 4-8 years) with myopia, emmetropia, and hyperopia were treated with 1% atropine twice daily for one week.
- Choroidal thickness (ChT) was measured using optical coherence tomography at baseline and after the one-week treatment period.
- Participants were categorized into three groups based on their refractive error: myopia, emmetropia, and hyperopia.
Main Results:
- Significant thickening of the subfoveal and parafoveal choroid was observed in both the myopia and emmetropia groups after atropine administration (p < 0.05).
- In contrast, hyperopic children exhibited no significant changes in overall ChT, with a notable exception of increased thickness on the nasal side (p < 0.05).
Conclusions:
- Topical 1% atropine effectively increases choroidal thickness (ChT) in the subfoveal and parafoveal regions of myopic and emmetropic children.
- The effect of atropine on choroidal thickness varies with refractive status, showing minimal impact in hyperopic children except for localized nasal changes.
Introduction:
The aim of the study was to assess changes in choroidal thickness (ChT) after administration of 1% atropine for 1 week in myopic, emmetropic, and hyperopic children.
Methods:
A total of 235 children aged 4-8 years, which included 46 myopia, 34 emmetropia, and 155 hyperopia patients, were recruited and divided into three groups according to the spherical equivalent with the use of 1% atropine twice a day for 1 week. The ChT was measured at baseline and 1 week.
Results:
In the myopia and emmetropia groups, following administration of 1% atropine gel, the ChT thickened significantly under the fovea (i.e., from 278.29 ± 53.01 μm to 308.24 ± 57.3 μm, p < 0.05; from 336.10 ± 78.60 μm to 353.46 ± 70.22 μm, p < 0.05, respectively), and at all intervals from the fovea, while in the hyperopia group, there was no significant difference in the ChT except the nasal side (p < 0.05).
Conclusion:
Topical administration of 1% atropine gel for 1 week significantly increased the subfoveal and parafoveal ChT in children with myopia and emmetropia. Atropine did not increase the ChT in hyperopic children, except on the nasal side.
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