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Updated: Aug 20, 2025

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Nanofiber Based on Electrically Conductive Materials for Biosensor Applications.

Seda Gungordu Er1, Alesha Kelly2, Sumudith Bhanuka Warnarathna Jayasuriya3

  • 1Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE UK.

Biomedical Materials & Devices (New York, N.Y.)
|November 23, 2022
PubMed
Summary
This summary is machine-generated.

Nanofibers offer a promising platform for advanced biosensing devices, enhancing sensitivity and enabling cost-effective, wearable diagnostics. This review explores their materials, fabrication, and applications in detecting biomarkers like cancer and DNA.

Keywords:
DiagnoseElectrochemicalElectrospinningImplantableNanofiber-based biosensorWearable

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Biotechnology

Background:

  • Biosensors are vital for real-time clinical diagnostics, translating analyte signals into measurable data.
  • Nanofiber technology presents a significant advancement for biosensing platforms due to unique structural properties.
  • The development of cost-effective, wearable biosensors is critical for point-of-care applications.

Purpose of the Study:

  • To review nanofiber-based biosensing platforms, focusing on materials, fabrication, and applications.
  • To explore the use of nanofibers in mechanical, electrochemical, and optical biosensors.
  • To discuss the challenges and future potential of nanofiber biosensors.

Main Methods:

  • Review of recent literature on nanofiber fabrication techniques.
  • Analysis of nanofiber properties relevant to biosensing (surface area, porosity, conductivity).
  • Examination of various transducer and bioreceptor integration methods.

Main Results:

  • Nanofibers provide a high surface-area-to-volume ratio and favorable microenvironments for bioanalytes.
  • Electrochemical biosensors predominantly utilize nanofibers, with growing use in optical and mechanical designs.
  • Functionalized nanofibers enhance biosensor efficiency for detecting cancer biomarkers, urea, DNA, and microorganisms.

Conclusions:

  • Nanofiber mats offer advantageous properties for biosensing applications.
  • Continued research into nanofiber design and fabrication can overcome current limitations.
  • Nanofiber-based biosensors hold significant potential for future diagnostic tools.