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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Related Experiment Video

Updated: Aug 20, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Beyond Neutrophils for Predicting Relapse and Remission in Ulcerative Colitis.

Hala El-Zimaity1, Seth R Shaffer2,3, Robert H Riddell4

  • 1Dynacare Laboratories, Toronto, Ontario, Canada.

Journal of Crohn'S & Colitis
|November 25, 2022
PubMed
Summary

In ulcerative colitis (UC) patients in remission, specific colonic histological features like left-sided plasmacytosis and eosinophils predict relapse. Intra-epithelial eosinophils, especially in the right colon, indicate persistent remission.

Keywords:
Ulcerative colitiseosinophilspathologyplasma cellsrelapse

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Area of Science:

  • Gastroenterology
  • Histopathology
  • Inflammatory Bowel Disease Research

Background:

  • Ulcerative colitis (UC) management requires predicting long-term remission.
  • Endoscopic remission does not always correlate with histological healing.
  • Identifying histological markers for relapse is crucial for UC patient care.

Purpose of the Study:

  • To determine which colonic histological features and biopsy sites predict relapse in UC patients achieving endoscopic remission.
  • To identify predictors of sustained remission in ulcerative colitis.

Main Methods:

  • Retrospective review of 166 UC patients in endoscopic remission over a median of 6 years.
  • Assessment of histological features including plasma cells and eosinophils using standardized grading.
  • Statistical analysis using logistic regression and survival analyses to identify relapse predictors.

Main Results:

  • Ulceration, particularly in the left colon, was a strong predictor of relapse.
  • Increased plasma cells in the basal lamina propria and eosinophils in the left colon predicted relapse in the absence of ulceration.
  • Intra-epithelial eosinophils, especially in the right colon, were associated with persistent remission.

Conclusions:

  • Left-sided plasmacytosis and increased lamina propria eosinophils are key indicators of relapse risk in UC patients in endoscopic remission.
  • The presence of intra-epithelial eosinophils suggests a favorable prognosis for sustained remission.
  • Histological assessment provides valuable prognostic information beyond endoscopic findings in UC.