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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Biofunctional Layered Double Hydroxide Nanohybrids for Cancer Therapy.

Joonghak Lee1,2,3, Hee Seung Seo4,5, Wooram Park6,7

  • 1Department of Engineering Chemistry, College of Engineering, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea.

Materials (Basel, Switzerland)
|November 26, 2022
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Summary
This summary is machine-generated.

Layered double hydroxides (LDHs) offer biocompatible, high-capacity nanocarriers for drug delivery. This review highlights LDH nanohybrids in advanced cancer therapies like gene therapy and chemotherapy.

Keywords:
cancer therapydrug delivery systemlayered double hydroxidenanohybrid

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Layered double hydroxides (LDHs) are 2D nanomaterials with excellent biocompatibility and drug loading capabilities.
  • The intercalation of DNA into LDHs has paved the way for developing novel nanohybrids for biomedical applications.
  • LDHs hybridized with therapeutic agents show significant promise in cancer imaging and targeted therapy.

Purpose of the Study:

  • To review recent advancements in the preparation of LDH nanohybrids.
  • To explore the application of LDH nanohybrids in various cancer therapeutic strategies.
  • To highlight the potential of LDHs in targeted cancer treatment.

Main Methods:

  • Literature review of recent research on LDH nanohybrids.
  • Analysis of preparation techniques for LDH-based nanostructures.
  • Synthesis and characterization of LDH-drug conjugates.

Main Results:

  • LDH nanohybrids have been successfully developed for various drug delivery systems.
  • These nanohybrids demonstrate efficacy in gene therapy, chemotherapy, immunotherapy, and combination therapy for cancer.
  • Targeting functions of LDH nanohybrids enhance their role in cancer imaging and treatment.

Conclusions:

  • LDH nanohybrids represent a promising platform for developing innovative cancer therapeutics.
  • Further research into LDH nanohybrid preparation and application will advance targeted cancer treatment strategies.
  • The unique properties of LDHs make them valuable for multifaceted cancer imaging and therapy.