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Chitosan/POSS Hybrid Hydrogels for Bone Tissue Engineering
Consuelo Celesti1,2, Daniela Iannazzo1, Claudia Espro1
1Department of Engineering, University of Messina, Contrada Di Dio, 98166 Messina, Italy.
Materials (Basel, Switzerland)
|November 26, 2022
Summary
Chitosan (CS) and polyhedral oligomeric silsesquioxanes (POSS) hybrid hydrogels show promise for bone regeneration. These nanocomposites exhibit enhanced properties and biocompatibility, making them suitable for tissue engineering applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Chitosan (CS) hydrogels are promising for bone tissue engineering.
- Polyhedral oligomeric silsesquioxanes (POSS) can enhance biopolymeric matrix properties.
Purpose of the Study:
- To design and characterize novel chitosan-POSS nanocomposites for bone regeneration.
- To investigate the effect of varying POSS concentrations on composite properties.
- To evaluate drug release and in vitro biological performance.
Main Methods:
- Synthesized CS/POSS hybrid hydrogels with different POSS concentrations (0.5, 1, 1.5 wt%).
- Characterized chemical, physical, and rheological properties.
- Assessed ketoprofen drug release kinetics.
- Performed in vitro cytotoxicity tests using human fetal osteoblastic cells (hFOB 1.19).
Main Results:
- CS/POSS hydrogels demonstrated improved properties compared to pure CS.
- Controlled ketoprofen release observed (86-91% over two weeks).
- Hybrid materials exhibited excellent biocompatibility with cell mortality comparable to controls (11.1% vs. 9.8%).
Conclusions:
- CS/POSS hybrid hydrogels are effective for bone tissue engineering.
- POSS incorporation enhances hydrogel performance and biocompatibility.
- These nanocomposites represent viable candidates for bone regeneration applications.
