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Updated: Aug 19, 2025
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Radiation-Induced Laryngeal Mucous Membrane Pemphigoid
Amit Syal1, David G Lott2, William E Karle2
1Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.
Objectives:
Bullous pemphigoid has previously been linked to radiotherapy, but here we report the first case of MMP suspected to be a consequence of RT.
Methods:
The patient described is an 85-year-old male who underwent RT to treat squamous cell carcinoma of the palatine tonsil. Shortly after therapy, the patient developed blisters with worsening dyspnea and dysphonia.
Results:
This patient was successfully treated with a combination of oral immunosuppressants and surgical intervention.
Conclusion:
This incident underscores that not all episodes of mucosal ulceration following radiation are a result of mucositis and MMP should be considered in the differential.
Level Of Evidence:
Level 4.
