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Updated: Aug 19, 2025

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
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Role of Ovarian Suppression in Early Premenopausal Breast Cancer
1Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, Univeristy of Melbourne, Melbourne, Australia; St Vincent's Hopsital Melbourne, Australia.
Abstract:
The benefit from removing ovaries to control premenopausal breast cancer growth was identified more than 100 years ago. Subsequent identification of estrogen receptor (ER) enabled targeting of this approach. Development of gonadotropin-releasing hormone agonists facilitated a reversible method of ovarian function suppression, suitable for young women with early breast cancer. Clinical trials have established the value of including ovarian suppression to reduce recurrence of ER-positive premenopausal early breast cancer. Ovarian suppression administered with chemotherapy can reduce the risk of premature menopause in ER-negative cancer, and increase the prospect of future pregnancy in premenopausal women, regardless of tumor hormone receptor status.
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