Changes in Brain Activity in Healthy Women during Self-Regulation of Slow EEG Activity in the Prefrontal Cortex

Frontal alpha asymmetry neurofeedback is used in affective disorders; however, little is known about the effects of this protocol on the composition of brain networks. In the current study, 13 healthy women underwent a course of self-regulation of the asymmetry of the EEG alpha or theta (control condition) band power. Before and after the course, resting state fMRI recordings were made. In the experimental group compared with the control group, the connectivity of the right occipital regions with the anterior cingulate, the left anterior insula, and the left caudate was blunted. Also, in the experimental group in the right hemisphere, the connectivity of the activity of the dorsal prefrontal cortex and the frontal pole was reduced. Thus, the experience of controlling the EEG alpha activity may specifically rearrange the functional connections of the emotional and motivational systems of the brain to the region of the maximum alpha amplitudes.