Silatrane-Sulfonamide Hybrids as Promising Antibacterial Agents

At the A. E. Favorsky Irkutsk Institute of Chemistry, a series of silatrane-sulfonamide hybrids 1a-d and 2a-d was synthesized. The antibacterial activity of 1a, 1b, 1d, 2a, and 2b against test strains of bacteria Yersinia pestis EV NIIEG, Yersinia enterocolitica 628/1, Listeria monocytogenes 766, and Starhylococcus aureus ATCC 6538-P (FDA 209-Р) was evaluated. The minimum inhibitory concentration for silatrane-sulfonamide hybrids was 100-200 mg/liter. Silatrane-sulfonamide hybrid 1d was the most active against all tested strains: minimum inhibitory concentration 100 mg/liter. Exposure to silatrane-sulfonamide hybrids in a doses of 100-200 mg/liter inhibited culture growth by 50-75%.