Related Experiment Video
Updated: Aug 19, 2025
Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
Published on: December 1, 2023
Systemic inflammation and risk of multiple sclerosis - A presymptomatic case-control study
Viktor Grut1, Martin Biström1, Jonatan Salzer1
1Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden.
Background:
C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS).
Objectives:
To assess CRP as a risk factor for MS.
Methods:
Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837 individuals who later developed MS and 984 matched controls. The risk of developing MS was analysed by conditional logistic regression on z-scored CRP values.
Results:
Levels of CRP were not associated with MS risk.
Conclusions:
We found no association between CRP levels and risk of MS development.
