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Microplasma-enabled carbon dots composited with multi-walled carbon nanotubes for dopamine detection
Jiaxin Zhou1, Yi Xia1, Zhirong Zou1
1College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, 610068, Sichuan, China.
Analytica Chimica Acta
|November 28, 2022
Summary
This study developed a novel carbon dots/multi-walled carbon nanotubes (CDs/MWCNTs) biosensor for sensitive dopamine detection. The innovative microplasma synthesis method offers a promising route for advanced carbon nanomaterial applications in biological assays.
Area of Science:
- Electrochemistry
- Materials Science
- Nanotechnology
Background:
- Composited carbon nanomaterials offer high sensitivity for biological assays due to their electrical properties and biocompatibility.
- Enhancing electron transfer and electrocatalytic activity is crucial for sensitive detection of biomolecules like dopamine.
- Glycerol-based carbon dots (CDs) and multi-walled carbon nanotubes (MWCNTs) are promising components for advanced electrochemical sensors.
Purpose of the Study:
- To develop a highly sensitive electrochemical biosensor for dopamine (DA) detection.
- To synthesize novel carbon dots (CDs) using a microplasma method and combine them with MWCNTs.
- To investigate the enhanced electron transfer and electrocatalytic activity of the CDs/MWCNTs composite electrode for DA detection.
Main Methods:
- Synthesized glycerol-based carbon dots (CDs) via liquid dielectric barrier discharge (DBD) microplasma.
- Constructed a composited carbon nanomaterial electrode by combining CDs with multi-walled carbon nanotubes (MWCNTs).
- Evaluated the electrochemical sensing performance of the CDs/MWCNTs electrode for dopamine detection in buffer and human serum samples.
Main Results:
- The CDs/MWCNTs electrode demonstrated enhanced electron transfer and electrocatalytic activity for DA detection.
- The sensor exhibited a linear detection range of 2.0-100 μM for DA, with a low limit of detection (LOD) of 11.08 nM.
- High sensitivity (29020 μA cm⁻² mM⁻¹) and satisfactory selectivity and recovery rates were achieved in human serum samples.
Conclusions:
- The developed CDs/MWCNTs composite electrode provides a sensitive and selective platform for electrochemical dopamine detection.
- The microplasma-based synthesis offers an efficient and promising approach for preparing advanced carbon-based nanomaterials.
- This work highlights the potential of nanomaterial composites in developing high-performance biosensors for clinical applications.
