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Related Concept Videos

Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

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Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
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Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
190
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

337
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Acute appendicitis and ulcerative colitis: a population-based sibling comparison study.

Miguel Garcia-Argibay1, Ayako Hiyoshi2,3,4,5, Scott Montgomery2,4,6

  • 1Clinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health, Örebro universitet, Örebro, Sweden miguel.garcia-argibay@oru.se.

BMJ Open Gastroenterology
|November 29, 2022
PubMed
Summary
This summary is machine-generated.

Individuals who had acute appendicitis before age 20 had a lower risk of developing ulcerative colitis (UC). This association appears independent of shared genetic and environmental factors within families.

Keywords:
appendicitisgeneticsinflammatory bowel diseaseulcerative colitis

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Area of Science:

  • Gastroenterology
  • Epidemiology
  • Genetics

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease with complex etiology.
  • Acute appendicitis is a common surgical condition with potential immunomodulatory effects.
  • Previous studies suggest an inverse relationship between appendicitis and UC, but confounding factors remain a concern.

Purpose of the Study:

  • To investigate the association between acute appendicitis and the subsequent risk of developing ulcerative colitis (UC).
  • To utilize a sibling comparison design to control for unmeasured familial genetic and environmental factors.

Main Methods:

  • A large-scale cohort study using Swedish national registers (1984-2018) including 3.1 million individuals.
  • Cox hazards models were employed to calculate UC risk in individuals with and without appendicitis by age 20.
  • Sibling-stratified analyses were performed to adjust for shared familial confounding.

Main Results:

  • A significantly decreased risk of developing UC was observed in individuals who had acute appendicitis before age 20 (HR=0.37).
  • The incidence of UC was 1.66 per 10,000 person-years in those with appendicitis versus 3.63 per 10,000 person-years in those without.
  • The association remained significant after adjusting for familial factors (HR=0.46), indicating a minimal role for shared confounders.

Conclusions:

  • Acute appendicitis in late adolescence is associated with a reduced risk of developing ulcerative colitis.
  • The findings suggest an independent association, implying that appendicitis or its underlying mechanisms may influence UC development.
  • Genetic and shared environmental factors appear to play a limited role in this observed inverse relationship.