Progress in copper-catalysed/mediated intramolecular dehydrogenative coupling

Area of Science:

• Organic Chemistry
• Catalysis

Background:

• Transition metal-catalyzed C-H functionalization is key for bond formation.
• Early methods relied on expensive metals; focus shifted to earth-abundant metals like copper.
• Copper catalysis presents a cost-effective, less toxic, and greener alternative.

Purpose of the Study:

• To comprehensively review copper-mediated intramolecular dehydrogenative coupling reactions.
• To highlight the synthesis of carbon-carbon and carbon-heteroatom bonds.
• To focus on copper's role in regioselective C-H activation.

Main Methods:

• Review of literature on copper-catalyzed intramolecular dehydrogenative coupling.
• Analysis of reactions involving C-H and heteroatom-H bond activation.
• Emphasis on reactions utilizing oxygen as the terminal oxidant.

Main Results:

• Copper catalysts enable regioselective activation of inert C-H bonds.
• Intramolecular dehydrogenative coupling efficiently produces complex polycyclic scaffolds.
• Oxygen is frequently employed as the terminal oxidant in these copper-catalyzed reactions.

Conclusions:

• Copper-based intramolecular dehydrogenative coupling is a powerful synthetic strategy.
• This approach offers a sustainable and efficient route to valuable molecular architectures.
• This review provides the first comprehensive account of copper-based intramolecular dehydrogenative coupling.