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Nirmatrelvir/Ritonavir Prescription Rate and Outcomes in Coronavirus Disease 2019: A Single Center Study

Jin Ju Park1, Jacob Lee2, Yu Bin Seo1

  • 1Division of Infectious Diseases, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Infection & Chemotherapy
|November 30, 2022
PubMed

Insights

Nirmatrelvir/ritonavir prescription rates were low in COVID-19 patients, mainly due to patient refusal. Treatment led to faster symptom resolution with no severe side effects, highlighting the need for accurate drug information.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Public Health

Background:

  • Nirmatrelvir/ritonavir is Korea's first oral antiviral for COVID-19.
  • Analysis of prescription rates and outcomes in eligible home-based care patients is crucial.

Purpose of the Study:

  • To evaluate the prescription rate of nirmatrelvir/ritonavir.
  • To determine treatment outcomes and reasons for non-prescription in COVID-19 patients.

Main Methods:

  • Retrospective data collection of COVID-19 patients eligible for nirmatrelvir/ritonavir.
  • Analysis of prescription patterns, refusal reasons, and patient outcomes.

Main Results:

  • Low prescription rate (26.8%); over 86% of non-prescriptions were due to patient refusal.
  • Shorter symptom duration in the prescription group (4.4 vs. 5.2 days).
  • No hospitalizations among those receiving nirmatrelvir/ritonavir; 15.3% experienced side effects.

Conclusions:

  • Low uptake of nirmatrelvir/ritonavir, primarily driven by patient refusal.
  • Nirmatrelvir/ritonavir demonstrated faster symptom resolution and a favorable safety profile.
  • Emphasized the need for providing accurate drug safety information for informed patient decisions.
Abstract

Keywords:
COVID-19Nirmatrelvir and Ritonavir Drug CombinationOutcome

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