Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Censoring Survival Data01:09

Censoring Survival Data

189
Survival analysis is a statistical method used to analyze time-to-event data, often employed in fields such as medicine, engineering, and social sciences. One of the key challenges in survival analysis is dealing with incomplete data, a phenomenon known as "censoring." Censoring occurs when the event of interest (such as death, relapse, or system failure) has not occurred for some individuals by the end of the study period or is otherwise unobservable, and it might have many different...
189
Causality in Epidemiology01:21

Causality in Epidemiology

638
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
638
Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

248
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
248
Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

500
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
500
Multiple Regression01:25

Multiple Regression

3.1K
Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
3.1K
Friedman Two-way Analysis of Variance by Ranks01:21

Friedman Two-way Analysis of Variance by Ranks

274
Friedman's Two-Way Analysis of Variance by Ranks is a nonparametric test designed to identify differences across multiple test attempts when traditional assumptions of normality and equal variances do not apply. Unlike conventional ANOVA, which requires normally distributed data with equal variances, Friedman's test is ideal for ordinal or non-normally distributed data, making it particularly useful for analyzing dependent samples, such as matched subjects over time or repeated measures...
274

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "GLP-1 receptor agonists for weight reduction in people living with obesity but without diabetes: a living benefit-harm modelling study" eClinicalMedicine 2024;73:102661.

EClinicalMedicine·2026
Same author

The association between sodium-glucose cotransporter 2 inhibitor and risk of pancreatic cancer among patients with type 2 diabetes mellitus: A real-world cohort study.

Medicine·2026
Same author

Targeted maximum likelihood estimation for mediation analysis with multiple time-varying mediators.

Biometrics·2026
Same author

Robust Estimation of Population Attributable Fractions in the Presence of Multiple Ordered Mediators.

Statistics in medicine·2026
Same author

Infertility treatment and the growth of children from birth to 12 years of age: A national cohort study.

PloS one·2026
Same author

Insights from a randomized controlled trial on a digital lifestyle intervention in non-small cell lung cancer survivors following inpatient rehabilitation.

Lung cancer (Amsterdam, Netherlands)·2026
Same journal

Can the All of Us sample be reweighted to mirror a nationally representative sample? A comparison of mortality predictors.

Epidemiology (Cambridge, Mass.)·2026
Same journal

Gut health, systemic inflammation, and linear growth among Indonesian infants: findings from the Action Against Stunting Hub observation cohort: Erratum.

Epidemiology (Cambridge, Mass.)·2026
Same journal

Evaluating Estimators in Partially Identified Models.

Epidemiology (Cambridge, Mass.)·2026
Same journal

Stratification and accumulation? Explaining changing mortality inequities between business owners and non-owners in the U.S. (1984-2022).

Epidemiology (Cambridge, Mass.)·2026
Same journal

Be wary of age-stratum aging in early-onset cancer trends.

Epidemiology (Cambridge, Mass.)·2026
Same journal

The Authors Respond.

Epidemiology (Cambridge, Mass.)·2026
See all related articles

Related Experiment Video

Updated: Aug 19, 2025

Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities
10:26

Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities

Published on: September 11, 2021

4.0K

Causal Mediation Analysis with Multiple Time-varying Mediators.

An-Shun Tai1,2, Sheng-Hsuan Lin2, Yu-Cheng Chu2

  • 1From the Department of Statistics, National Cheng Kung University, Tainan, Taiwan.

Epidemiology (Cambridge, Mass.)
|December 1, 2022
PubMed
Summary
This summary is machine-generated.

This study extends the mediational g-formula to analyze multiple time-varying mediators, crucial for understanding complex health conditions like COPD. The new method reveals how symptoms and activity levels mediate disease progression.

Area of Science:

  • Causal inference
  • Epidemiology
  • Biostatistics

Background:

  • Longitudinal studies with time-varying exposures and mediators are common in health research.

More Related Videos

Task Interruption and Resumption Paradigm for Testing the Activation and Pursuit of an Abstract Thinking Goal
06:45

Task Interruption and Resumption Paradigm for Testing the Activation and Pursuit of an Abstract Thinking Goal

Published on: April 18, 2017

6.3K
Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments
13:00

Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments

Published on: January 23, 2017

10.0K

Related Experiment Videos

Last Updated: Aug 19, 2025

Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities
10:26

Problem-Solving Before Instruction PS-I: A Protocol for Assessment and Intervention in Students with Different Abilities

Published on: September 11, 2021

4.0K
Task Interruption and Resumption Paradigm for Testing the Activation and Pursuit of an Abstract Thinking Goal
06:45

Task Interruption and Resumption Paradigm for Testing the Activation and Pursuit of an Abstract Thinking Goal

Published on: April 18, 2017

6.3K
Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments
13:00

Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments

Published on: January 23, 2017

10.0K
  • Existing mediational g-formula methods are limited to single mediators, restricting their application.
  • Complex causal pathways often involve multiple interacting mediators.