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Related Experiment Video

Updated: Aug 19, 2025

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
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Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

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Extracellular vesicles as personalized medicine.

Danielle J Beetler1, Damian N Di Florio1, Katelyn A Bruno2

  • 1Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, 55902, USA; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA.

Molecular Aspects of Medicine
|December 1, 2022
PubMed
Summary

Extracellular vesicles (EVs) are cell-specific messengers crucial for intercellular communication. This review explores their potential as biomarkers and therapeutics for personalized medicine in various diseases.

Keywords:
CancerImmune responseNanomedicineNeurological diseaseRegenerative medicineViruses

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Area of Science:

  • Cell biology
  • Biochemistry
  • Biomedical engineering

Background:

  • Extracellular vesicles (EVs) mediate intercellular communication, influencing health and disease.
  • EV contents are cell-specific, eliciting distinct responses in recipient cells.
  • EVs are accessible via liquid biopsies, making them promising biomarkers and therapeutic agents.

Purpose of the Study:

  • To review the multifaceted roles of EVs in health and disease.
  • To highlight the application of EVs as biomarkers, drug delivery vehicles, and regenerative therapeutics.
  • To discuss the potential of EVs in personalized medicine.

Main Methods:

  • Literature review of studies on extracellular vesicles.
  • Analysis of EV roles in viral infections, cancer, and neurological diseases.
  • Evaluation of EV potential for personalized therapy.

Main Results:

  • EVs serve as critical mediators of intercellular signaling.
  • EVs demonstrate potential as biomarkers for disease diagnosis.
  • EVs show promise as vehicles for drug delivery and regenerative medicine.

Conclusions:

  • EVs are versatile tools with dual roles as therapeutic and pathological agents.
  • The cell-specific nature of EVs supports their use in personalized medicine.
  • Further research is needed to fully elucidate EV functions and optimize their clinical applications.