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Updated: Aug 19, 2025

Author Spotlight: Developing a Microfluidic Lung-on-Chip Model for In-Depth Study of Human Immune Response and Infection Mechanisms
Published on: May 31, 2024
Dynamic model of respiratory infectious disease transmission by population mobility based on city network
Zuiyuan Guo1, Jiangfan Li1, Guangquan Xiao1
1Infectious Disease Prevention and Control Division, Beibu Zhanqu Center for Disease Control and Prevention, Shenyang, People's Republic of China.
Abstract:
In modern societies, newly emerging infectious diseases spread rapidly between regions owing to frequent contact between people, causing considerable social and economic impacts. In this study, first, a scale-free city network was established, and then the shortest path between any two nodes was determined. Second, the movement path of tourists was designed based on the shortest path. Subsequently, every infected person's information, such as the city, infection time, onset and hospitalization, was confirmed based on their movement path. Third, the features of the transmission path and time distribution of the epidemic were characterized after summarizing the information. Finally, the reliability of the model was verified. The number of citizens and tourists in every city remained stable during this time. The results indicated that a larger basic reproduction number (R 0) and population outflow rate signify a faster growth rate of infected people in each city in the network. Compared with small and medium-sized cities, the epidemic spread faster in central cities. Population mobility was the decisive factor causing the spread of the epidemic to other areas. Therefore, the rapid spread of epidemics can be prevented by swiftly reducing the flow of people between cities.
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