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Updated: Aug 18, 2025

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Dual action of a tyrosinase-mesoporous silica nanoparticle complex for synergistic tissue adhesion
Su-Hwan Kim1,2, Kwangsoo Shin3,4, Byung-Gee Kim2,5,6
1Department of Chemical Engineering (BK21 FOUR), Dong-A University, Busan, 49315, Republic of Korea.
Abstract:
Bridging biological tissues for immediate adhesion and long-term sustainability was accomplished using a combination of mesoporous silica nanoparticles (MSNs) and tyrosinase. Tyrosinase-loaded MSNs provided rapid physical adsorption, while tyrosinase within MSNs induced enzymatic chemical bond gluing of tissues. This synergistic strategy has robust potential in tissue adhesives for clinical settings.
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