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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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New-Onset Guttate Psoriasis: A Long-Term Follow-Up Study
Eran Galili1, Shir Rubinstein Levy2, Ido Tzanani1
1Department of Dermatology, Tel Aviv University, Tel Aviv, Israel.
Dermatology (Basel, Switzerland)
|December 8, 2022
Summary
Guttate psoriasis (GP) often persists long-term, with nearly half of patients experiencing active disease after several years. Male sex, multiple flares, and developing psoriasis vulgaris are linked to persistent guttate psoriasis.
Area of Science:
- Dermatology
- Clinical Research
- Epidemiology
Background:
- Guttate psoriasis (GP) is a distinct psoriasis variant more prevalent in pediatric and adolescent populations.
- The long-term prognosis of GP, including relapse rates, persistence, and evolution to psoriasis vulgaris, is not well-documented.
Purpose of the Study:
- To investigate the long-term outcomes of new-onset guttate psoriasis.
- To identify factors associated with a persistent disease course in GP patients.
Main Methods:
- Retrospective cohort study of 120 patients diagnosed with new-onset GP between 2009-2020.
- Minimum follow-up of 1 year, with data collected on demographics, disease characteristics, treatments, and comorbidities.
- Telephone questionnaires assessed current psoriasis status; persistent disease defined as lesions present at least one year post-onset.
Main Results:
- After a mean follow-up of 6.2 years, 49.1% of patients had persistent psoriasis.
- 17.5% of patients transitioned to the psoriasis vulgaris phenotype.
- Factors associated with persistence included male sex (OR=2.1), multiple flares (OR=9.1), switching to vulgaris phenotype (OR=4.16), and palmoplantar involvement (OR=5.2).
Conclusions:
- Persistent disease is a common outcome for individuals with new-onset guttate psoriasis.
- The majority of patients maintain the guttate phenotype.
- Male sex, recurrent GP flares, transition to psoriasis vulgaris, and palmoplantar disease are significant predictors of persistence.
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