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Differences in biomarker concentrations in serum and urine of patients with Ocular Tuberculosis - A prospective
Fredrich J van der Colff1, Candice Snyders2, Gerhard Walzl2
1Division of Ophthalmology, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town, 8000, South Africa.
Purpose:
To describe biomarker concentrations in serum and urine of South African patients with ocular tuberculosis (OTB).
Methods:
A prospective study to compare 29 urine and serum biomarkers in 14 OTB patients at a tertiary eye clinic.
Results:
Median age of participants (7 male and 7 female) was 38.5 years (range 25-73) Most biomarker concentrations were significantly higher in serum than in urine (p < 0.01). Only 2 (IL-1RA and IL-2) showed higher concentrations in urine than serum (p < 0.01). Three biomarkers (sIL-2Ra, sTNFRI and IFNγ) showed no difference in concentration between urine and serum (p > 0.05).
Conclusions:
Most biomarkers tested showed significant differences in concentration between serum and urine and therefore these 2 biofluids cannot be used interchangeably when studying biomarker profiles. One notable exception is IFNγ as its concentration did not differ between serum and urine.
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