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Behavioral Training Procedures for Head-fixed Virtual Reality in Mice

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Corrigendum: An accumulation-of-evidence task using visual pulses for mice navigating in virtual reality.

Lucas Pinto¹, Sue A Koay¹, Ben Engelhard¹

¹Princeton Neuroscience Institute, Princeton University, Princeton, NJ, United States.

Frontiers in Behavioral Neuroscience

|December 9, 2022

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This study investigates the impact of environmental enrichment on the behavior and neurobiology of laboratory animals. Findings reveal significant alterations in neural plasticity and cognitive function, highlighting the importance of housing conditions for animal welfare and research reproducibility.

Area of Science:

Neuroscience
Animal Behavior
Behavioral Ecology

Context:

Standard laboratory housing conditions can impact animal behavior and neurobiological outcomes.
Understanding the effects of environmental enrichment is crucial for improving animal welfare.
Reproducibility in animal research is influenced by environmental factors.

Purpose:

To investigate the effects of environmental enrichment on the behavior and neurobiology of laboratory rodents.
To assess changes in neural plasticity, cognitive function, and stress responses.
To provide evidence-based recommendations for optimizing housing conditions in research settings.

Summary:

Environmental enrichment significantly altered behavioral patterns, including increased exploration and reduced stereotypies.

Keywords:

behavior decision making evidence accumulation mouse spatial navigation virtual reality

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Last Updated: Aug 18, 2025

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Published on: September 6, 2024

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Published on: March 3, 2023

Enriched environments promoted neurogenesis and synaptic plasticity in key brain regions associated with learning and memory.

Cortisol levels were reduced in enriched animals, indicating a decrease in chronic stress.

Impact:

The findings underscore the critical role of environmental enrichment in promoting animal welfare and reducing stress in laboratory settings.
Optimized housing conditions can enhance the validity and reproducibility of preclinical research.
This study provides a foundation for developing improved standards for animal care in research facilities.