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Updated: May 1, 2026

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
[A particular presentation of a T cell large granular lymphocytic leukaemia]
Marie Donzel1, Mathilde Bon Mardion2, Brigitte Balme1
1Hospices civils de Lyon, Institut de pathologie multisite, centre hospitalier universitaire Lyon Sud, Pierre-Bénite, France.
Abstract:
T cell prolymphocytic leukemia (T-PLL) is a rare, aggressive neoplasm derived from post-thymic T cells. Patients are typically middle-aged with a slight male predominance who present with a high white blood cell count, hepatosplenomegaly, lymphadenopathy, and other symptoms typically associated with leukemia. Although cutaneous involvement has been reported in up to 30% of cases of T-PLL, to our knowledge, none have presented with a presentation resembling livedoid vasculopathy. In the correct clinical context, an underlying hematolymphoid neoplasm should be included in the differential diagnosis of a patient presenting with livedoid vasculopathy.
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